（ Department of Chemistry, Seoul National University, Seoul 151-747, Korea）
Designing, synthesizing and controlling plasmonic nanostructures such as Au and Ag nanoparticles (AuNPs and AgNPs) with high precision and high yield are of paramount importance in optics, nanoscience,materials scienceand nanobiotechnology. It is particularly important to generate and control ~1-nm plasmonic gap because plasmonic gaps of ~1 nm or less can generate exponentially stronger plasmonic coupling signals than >1-nm plasmonic gap. Among many examples of the use of plasmonic nanogap, surface-enhanced Raman scattering(SERS)-based signal amplification and bio-detection methods using SERS-active plasmonic nanoparticles (NPs) have been drawing significant interest, and it has been known that SERS effect isveryintense when Raman dyes are located within <1 -nm inter-particle junction. here, i will describe dna-based synthetic strategies to build up new types of plasmonic nanogap au/ag structures with high structural controllability. the use of these plasmonic nanostructures including anisotropic nanostructures as excellent optical signal enhancement platforms in detecting biomolecules sensitively, quantitatively and specifically will be presented especially for ~1-nm plasmonic gap probes. otherbiosensingapplications of these plasmonic probesincluding plasmonic nanoprobe-tethered supported lipid bilayer system will be also shown and discussed in this presentation.